Pcr complete response8/13/2023 Identical methods to recover the IPD data were used for both the pCR and non-pCR groups within each study to reduce bias.Despite the improvement in the treatment of early stage breast cancer with cytotoxic chemotherapy to eradicate occult metastatic disease, a subgroup of patients continues to be at high risk for recurrence and death. Alternatively, if KM curves were not available, method two used either a measure of median survival or a landmark event and assumed an exponential distribution to impute the IPD from the metric. If available, method one used the KM curves to reconstruct the IPD data via the method of Guyot and colleagues ( 9). We obtained the individual patient data (IPD) used in our analysis from the selected manuscripts by one of two methods. When available, outcomes based on the major breast cancer subtypes were extracted. Data extractionįor each selected manuscript, the following information was recorded by two independent reviewers: primary author name, year of publication, sample size, duration of follow-up, definition of pCR, patient and tumor characteristics, neoadjuvant regimen, adjuvant regimen if applicable, number of patients achieving a pCR, and number of outcome events by pCR status. Furthermore, only those publications where individual patient-level data were extractable either in the form of Kaplan–Meier (KM) curves with event data and/or survival estimates (e.g., median survival, and/or another landmark event such as 5-year survival with event data) were included. Studies were excluded from subanalyses based on receptor subtypes if HER2 status was unknown. Endocrine therapy–based neoadjuvant studies and neoadjuvant studies with radiation were also excluded. Studies including any neoplasm other than female breast cancer were excluded, as well as studies analyzing unresectable or metastatic breast cancer. Publications were included regardless of neoadjuvant regimen received. Inclusion criteria were clinical trials, prospective cohort studies, or retrospective cohort studies that reported pCR results after neoadjuvant chemotherapy as well as breast cancer recurrence and/or survival stratified by the presence or absence of pCR, with a total sample size of 25 patients or greater. 6), but is less understood for hormone receptor–positive (HR +)/HER2 − breast cancer, where pCR is less common and adjuvant endocrine therapy is the mainstay of systemic therapy. The association of pCR with improved long-term outcomes is recognized for HER2-positive (HER2 +) breast cancer and triple-negative (TN) breast cancer (TNBC ref. In addition, clinical subtype of breast cancer is an important factor to consider given differences in tumor biology as well as targeted therapy usage. Furthermore, these studies did not evaluate the impact of pCR on the utility of adjuvant therapy, which could potentially influence the clinical outcomes in patients with localized breast cancer. However, most neoadjuvant trials are powered to detect a difference in pCR among regimens, and likewise are not powered for long-term outcomes. Similarly, a meta-regression of 29 randomized prospective studies of NAT demonstrated pCR to be a strong prognostic factor, but the magnitude of relationship between pCR and EFS varied by type of NAT ( 5). In a pooled analysis of 12 clinical trials by Cortazar and colleagues, the authors demonstrated that pCR is associated with improved event-free survival (EFS), but the association between the magnitude of treatment-induced pCR change and corresponding improvement in EFS could not be established (i.e., delta pCR and delta EFS ref. While pCR demonstrates sensitivity to agents received in the neoadjuvant setting, true demonstration of treatment efficacy is dependent on its ability to predict long-term outcomes of recurrence and death, and this issue has not been completely settled in the literature. Yet, the prognostic significance of pCR after neoadjuvant chemotherapy remains somewhat controversial.
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Joplin movie theater shooting8/13/2023 My work in Kenya, for example, was heavily influenced by a Christian Science Monitor article I had forced myself to read 10 years earlier. “Many things that end up” being meaningful, writes social scientist Joseph Grenny, “have come from conference workshops, articles, or online videos that began as a chore and ended with an insight. "We are stunned and deeply saddened by this tragic incident, and our prayers are with Derek's family," MSSU Interim President Alan Marble said in a statement on the university's website.Ībout a year ago, I happened upon this statement about the Monitor in the Harvard Business Review – under the charming heading of “do things that don’t interest you”: He previously coached three seasons at Western Illinois University in Macomb, Ill., according to the MSSU website. Moore, 37, was in his first year on the Missouri Southern football staff. The Jasper County prosecutor's office did not immediately return a call Saturday. A jail official said the suspect could not take phone calls. Police said a 39-year-old suspect was arrested shortly after the shooting and was being held Saturday at the Joplin City Jail on a 24-hour hold pending formal charges. He found joy in giving – in ways big or small, recognized or not, always with a smile.Ī new assistant football coach at Missouri Southern State University was shot and killed as he was leaving a Joplin movie theater, authorities said Saturday.ĭerek Moore, offensive line coach for MSSU, was shot Friday night in the parking lot of the Northstar 14 Theatres, Joplin police said. And I’m starting to think that was his secret. Though he never wanted gifts, he left us with so many. His face lit up as he responded, “Seeing all of you happy!”He seemed to have a similar approach to life. Like helping several of his siblings immigrate to the U.S., filling out endless paperwork, and supporting them in finding housing, schooling, and jobs. Like helping relatives move from state to state countless times, driving U-Hauls and hauling boxes. Like volunteering as a chaplain at Syracuse University and local hospitals, driving an hour to campus after a full day’s work as an engineer, stopping at home to pack a peanut butter and jelly sandwich for his dinner. Like helping his youngest daughter through a mid-pandemic move and pregnancy, bringing me home-cooked meals and boxes full of practical gifts like toothpaste, pantry goods, and vitamins – all while enduring grueling health challenges. My dad died two years ago. On the drive back home, I asked him what his fun was on this trip. What motivated him was a mystery to me.Once, on a family road trip, he made sure we hit all the favorites for everyone in the family – a garden and gift shop for my mom and sister, a theme park with death-defying roller coasters for my brother and other sister. In fact, at that time, many people didn’t even know their exact birthday, much less have big celebrations. So Dad, who immigrated to the United States in 1967, was oddly immune to those pleasures other dads around us enjoyed, like beach vacations or fancy cars. Born in a modest home in 1940 as one of 10 kids to pragmatic parents in Hyderabad, India, my dad didn’t grow up celebrating the many Hallmark holidays we’re accustomed to today. We never celebrated Father’s Day growing up. Samsung tv samba8/13/2023 There are guides on youtube for how to sideload apps, so at least there is a workaround. i have to sideload android apps not available on androidtv. Xiami Mi Box might be okay if you want something more budget (it's one of the few that at least supports netflix 4k streaming)Īndroid is nice since it has a wide app eco system, i can install many useful apps to run on the hdtv.Īndroidtv i found was more of a hassle. ia-shield/Ĭan also use plex and kodi running on your nvidia shield, then point the media shares to the NAS to stream the content from (on the lan network).Īlternatively you can connect the qnap to hdtv via hdmi and use the hdstation to use the qnap native apps if you prefer.īut honestly, i recommend nvidia shield because it just works. The network location is now available for use with libraries on your Plex Media Server. You can now verify that the location was mounted successfully: 1 mounted will appear under Network Storage in the list. Enter the username and password for the network location.ĥ. Under Available Network Storage, select your device and then choose Connect as a registered user.Ĥ. Choose Storage & reset then Network Storage.ģ. Open the NVIDIA SHIELD device Settings.Ģ. Please consult your NAS or other device’s documentation for details and to ensure access privileges are properly setup.ġ. You may need to configure a username and password on your NAS or network share to access it across a network. The SHIELD makes use of the “SMB” protocol to connect to network locations, so you will want to ensure that your network device supports that (nearly all do). That way, you’ll be able to make use of media stored in those network locations for your Plex Media Server. If you have a NAS (network attached storage) device, a hard drive connected to your router, folders from your computer shared on the network or other storage locations available across your local network, you can connect to those from the NVIDIA SHIELD. Note: You need to ensure that you’ve updated Plex Media Server via the Google Play Store to have SMB support on the SHIELD. I would like to go directly to my media (eg. Is this possible somehow? Symlinks? how and where?Īnother thing is that my multimedia are mixed (photos + short video clips in one directory).īut now I must choose the media file first (pictures or video) and click down,īecause the system is showing media of one type only. Through which I must click through down to my files. If I select source:NAS etc, I get a complicated I want to access these files through Samsung TV To which I copy structured folder with rsync Of my linux computer and one for multimedia. CTA did not verify the accuracy of any submission or of any claims made and did not test the item to which the award was given.I have created 2 volumes, one for rsync backup ¶¶ The CES Innovation Awards are based upon descriptive materials submitted to the judges. Any reliance on these results is at the third party’s own risk. Results are not an endorsement of Samsung. The American Customer Satisfaction Index (ACSI ®) is a national measure of customer satisfaction since 1994, trusted by US government and reflecting annual feedback from more than 250K US consumers. ACSI is a registered trademark of American Customer Satisfaction Index LLC. †† Based on the 2022 American Customer Satisfaction Index survey of customers rating their own TVs. CTA did not verify the accuracy of any submission or of any claims made and did not test the item to which the award was given. ◊The CES Innovation Awards are based upon descriptive materials submitted to the judges. The LST7T TV can be exposed to ambient or non-direct sunlight, but direct sunlight must be avoided. The Terrace Partial Sun LST7T is designed for placement and use in outdoor shaded environments. ‡Only The Terrace Full Sun LST9T can be placed in the sun. Supports TV models 2022 Neo QLED 8K and 4K, QLED 4K, and The Frame. Place it in your living room while your lights are turned on, or, alternatively, place it near a window where it will soak in natural sunlight. *To charge the remote with solar energy, set it down with the solar panel facing up. #Content services may vary by regions and are subject to change without notifications. Recording booth door8/13/2023 They prevent the transmission of environmental vibrations into the studio and also prevent vibrations within the studio from being transmitted outside. MECART studios and sound booths are designed to mitigate ambient sources of noise to a required level, depending on the types of use. Our team can also evaluate reverberation time in octave or 1/3 octave frequency bands, depending on whether you would be using the studio for music, speech, radio or some other purpose. MECART experts in acoustics can calculate and validate the optimal proportions for your studio in terms of available space. 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Original pacman characters8/13/2023 The red, green, and blue channels are defined by the bit pattern BBGGGRRR which allows for eight levels of intensity for red and green and four levels for blue. The PROM stores a palette of 256 colors in a single byte. The original arcade version of Pac-Man uses a hardware-based color PROM to determine its colors. /play/1014631/Classic-Game-Postmortem-PAC - Postmortem.Īlthough Pac-Man doesn't feature credits, fans of the game have discovered the majority of the design staff.Sure, it's from 1980, and you can't expect much, but it's extremely repetitive and not very rewarding to play. There is a minor bug with collision detection where you can sometimes pass right through a ghost.Sure, the kill screen ends the game, but it's insanely difficult to reach, and wasn't even intended in the first place. The game lacks a true victory condition.In fact, this is precisely how professional players play the game and it's incredibly boring to watch. Since the game's pseudo-randomizer is based on past performance, players can game how it functions and just repeat the exact same movements over an over again to beat the game.You're essentially repeating the same actions the entire game. Overall, there isn't much to do with the game.Most players are unable to beat the first level on their first attempt, which is a bit frustrating. The game has some pretty memorable sound effects and jingles.The cut-scenes between levels was a nice break in the action.Changing the bonus fruit is a nice change of pace.Adding a different "personality" to each ghost was a wonderful idea and really adds to the challenge, as did having the ghosts systematically move toward their own corners.The increasingly difficult ghosts and shorter-length power pellets increase the challenge of the game at a nice steady rate.It remains challenging and fast-moving the entire time you play. I've never tried hard to get a decent score, and I've never even come close to the kill screen. The game is just too primitive to keep my interest. I've since watched people who are really good play Pac-Man in arcades, but I've never had much of a desire to get good myself. I remember my brother playing and getting to the second stage, but I, being 3-years-younger, couldn't get past the first. I was with my mother and brother, I think at a laundromat in Pontiac. I remember first playing this game in the mid-1980s. Bluetooth spy camera price8/13/2023 For your research you would need to ensure that you are using the most trustworthy and highly reliable, websites or other sources.ĭo you have what it takes? Do you have the skills and resources to do it for yourself? Such sources may include online forums, word-of-mouth, rating websites, buying guides, and product reviews. Sources you may want to explore may include anything that can give you the information related to your need. 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